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Thread: Help! multiple PGD/IVF attempts failed... implantation

  1. #1
    Join Date
    Jun 2013
    Posts
    7

    Default Help! multiple PGD/IVF attempts failed... implantation

    Hello - would really really appreciate help and ideas

    3 natural pregnancy - 2 stopped due to genetic deformation in the embryo skeleton at week 16, 1 didn't develop

    We know the problematic gene (25% of passing to embryo)

    I'm after 8 rounds of PGD/IVF/Frozen (over 1-2 years):
    - 5 rounds of PGD (long and short cycles)
    - 2 rounds of frozen
    - 1 round of IVF

    In all the rounds I had good response to medicine
    In all rounds I had ~10 eggs, returned 2-3 embryos, day 5 baltocist in almost all attempts, sometimes with hatching

    Histroscope is ok, uterus scanning is ok, blood clotting ok
    I tried pipel before one of the attempts, and steroids in another

    Feel like I tried everything and nothing is working
    I'm lost

    Would love ideas... thoughts... anything I can do? (we are afraid to try natural and get another sick baby)
    Can there be things in implantation we didn't think about? What can we do about them?

    many many many thanks for the help

  2. #2
    Join Date
    Sep 2008
    Posts
    677

    Default

    After PGD, were only genetically and chromosomally normal embryos transferred? If so, you should talk with your doctor about being tested for both immunologic and thrombophilic risk factors for implantation failure. For more information about the tests included in the Implantation Failure and thrombophilia panels, you may go to the information on this website or visit the website of FCLab at FCLab.us. Dr. Coulam

  3. #3
    Join Date
    Jun 2013
    Posts
    7

    Default Many thanks for your quick reply

    Dear Dr. Coulam,

    Many thanks for your reply.

    Indeed only genetically and chromosomal normal embryos transferred (2-3 in every attempt)
    I have done thrombophilic tests and they came back ok.
    My Dr. didn't send me to immunologic tests yet as he said that the fact that I had 3 pregnancies in the past is an indication that it is probably not the problem. I will ask him again.

    Thanks again

  4. #4
    Join Date
    Sep 2008
    Posts
    677

    Default

    Things can change. You are doing the correct thing. Dr. Coulam

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