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Thread: Help! multiple PGD/IVF attempts failed... implantation

  1. #1
    Join Date
    Jun 2013

    Default Help! multiple PGD/IVF attempts failed... implantation

    Hello - would really really appreciate help and ideas

    3 natural pregnancy - 2 stopped due to genetic deformation in the embryo skeleton at week 16, 1 didn't develop

    We know the problematic gene (25% of passing to embryo)

    I'm after 8 rounds of PGD/IVF/Frozen (over 1-2 years):
    - 5 rounds of PGD (long and short cycles)
    - 2 rounds of frozen
    - 1 round of IVF

    In all the rounds I had good response to medicine
    In all rounds I had ~10 eggs, returned 2-3 embryos, day 5 baltocist in almost all attempts, sometimes with hatching

    Histroscope is ok, uterus scanning is ok, blood clotting ok
    I tried pipel before one of the attempts, and steroids in another

    Feel like I tried everything and nothing is working
    I'm lost

    Would love ideas... thoughts... anything I can do? (we are afraid to try natural and get another sick baby)
    Can there be things in implantation we didn't think about? What can we do about them?

    many many many thanks for the help

  2. #2
    Join Date
    Oct 2008


    There are many issues we need to look at. Some that come to mind are:
    1) The quality of the embryos on and before day 3 (egg issues)
    2) Was day 5 ET attempted
    3) Sperm factor - SDI test - sperm DNA kicks in after day 3
    4) Uterine scar tissue - result of Fluid US or office hysteroscopy
    5) Immune issues - NK test and APLA testing at
    6) ET technique
    7) Thickness of the uterine lining at ET (>9mm best)
    8) Type of protocol used - decrease amount of LH (repronex or menopur), decrease overall dose
    9) Appropriate coasting method.
    10) Check for insulin resistance - metformin only if elevated fasting insulin
    Hope that helps. Sorry for the late reply

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